FILTER CLEAR FILTERS

SORT date author


FILTER RECORDS BY


Daniel (6th century BCE)
The Book of Daniel, Chapter 1:1-16.

View

al-Razi (10th century CE)
Shukuk ala Jalinus. [Doubts about Galen]

View

Ibn Hindu (10th-11th century CE; 4th-5th century AH)
Miftah al-tibb wa-minhaj al-tullab [The key to the science of medicine and the students' guide].

View

Ben Cao Tu Jing (11th century)
Atlas of Materia Medica. Song Dynasty (960-1279).

View

Abd al-Latif ibn Yusuf al-Baghdadi (13th century CE, 7th century AH)
The Book of the Two Pieces of Advice by Abd al-Latif, the son of Yusuf, to the General Public (Kitab al-Nasihatain min Abd al-Latif b. Yusuf ila l-nas kaffatan). Bursa: MS Hüseyin Çelebi 823, item number 5; medical section on fol. 62a-78a; philosophical section: fol. 78b-100b.

View

al-Razi (10th century CE; 4th century AH)
Kitab al-Hawi fi al-tibb [The comprehensive book of medicine].

View

Ibn Sīnā (c.1012 CE; c.402 AH)
Kitab al-Qanun fi al-tibb [Avicenna’s The Canon of Medicine].

View

Bacon, Roger (1266)
Opus maius. MS Digby 325, 15th century manuscript. Bodleian Library, Oxford.

View

Petrarca F (14th century)
Letter to Boccaccio. Print: Senilium Liber V Epistola iii in: Annotatio nonnullorum librorum seu epistolarum Francisci Petrarche. Venetiis: Torresanus de Asula (1501). Manuscript: Key passage in the late 14th / early 15th century manuscript Biblioteca Marciana Lat. XI 17 / Francesco Petrarca; fol. 28r, second column, lines 9 – 22. (Facsimile of MS: Petrarca F (2003). Seniles, (eds Stocchi MP, Marcon S). Venice: Marsilio.)

View

Fioravanti L (1573)
Communication addressed to "Illustrissimo e Eccellentissimo Signor Al Protofisico Boldon e al Vicario di Giustizia", 22 xxxx 1573.

View

Stuart, James, King of Great Britaine, France and Ireland (1616)
A counterblaste to tobacco. In: The workes of the most high and mightie prince, James Published by James, Bishop of Winton, and Deane of his Majesties Chappel Royall. London: printed by Robert Barker and John Bill, printers to the Kings most excellent Majestie, pp 214-222.

View

Harvey W (c.1640-1657)
Marginalia. In: Aelius Galenus (1640). ΓΑΛΗΝΟΥ, Πρὸς ΘΡΑΣΥΒΟΥΛΟΝ, περὶ ἀρίστης αἱρέσεως. Galeni, De optima Secta, ad Thrasybulum. In: Goulston DT (editor). Galeni Opuscula hoc Libro comprehensa. London: Richard Badger, pp. 66–143.

View

Bacon F (1645)
Franc Baconis de Verulamio / Summi Angliae Cancellarii /Novum organum scientiarum. Lugd. Bat: apud Adrianum Wiingaerde, et Franciscum Moiardum. Aphorism XLVI (pages 45-46).

View

Starkey G (1657)
Natures explication and Helmont’s vindication…Or A short and sure way to a long and sound life. London: printed by E. Cotes for Thomas Alsop at the two Sugar-loaves over against St. Antholins Church at the lower end of Watling Street.

View

Nettleton T (1722)
Part of a letter from Dr. Nettleton, physician at Halifax, to Dr. Jurin, R. S. Sec concerning the inoculation of the small pox, and the mortality of that distemper in the natural way. Philosophical Transactions of the Royal Society of London (1722-1723) 32:209-212.

View

Massey I (1723)
A short and plain account of inoculation. With some remarks on the main argument made use of to recommend that practice, by Mr. Maitland and others. To which is added, a letter to the learned James Jurin, M.D.R.S. Secr. Col. Reg. Med. Lond. Soc. London: W. Meadows.

View

Clifton F (1732)
The state of physick, ancient and modern, briefly considered: with a plan for the improvement of it. London printed by W Bowyer, for John Nourse without Temple-Bar.

View

Smellie W (1752)
A treatise on the theory and practice of Midwifery. 2nd edition. London: D. Wilson, T Durham, p 224.

View

Hillary W (1761)
An inquiry into the means of improving medical knowledge. London: Hitch and Hawes.

View

Lind J (1762)
An essay on the most effectual means of preserving the health of seamen, in the Royal Navy. London: D Wilson.

View

Pierce R (1763)
Quoted in Sutherland A. Attempts to revive ancient medical doctrines Volume 1. London: A Millar, pp xxiii-xxiv.

View

Lind J (1763)
Two papers on fevers and infection. London: D Wilson.

View

Watson W (1768)
An account of a series of experiments, instituted with a view of ascertaining the most successful method of inoculating the smallpox. London: J Nourse.

View

Society of Gentlemen in Scotland (1771)
Medicine. Encyclopaedia Britannica. Vol 1. Edinburgh: Bell & Macfarquhar, pp 630-632.

View

Aikin J (1771)
Thoughts on hospitals. London: Joseph Johnson.

View

Lind J (1771)
An essay on diseases incidental to Europeans in hot climates. London: Becket and De Hondt.

View

Gregory J (1772)
Lectures on the duties and qualifications of a physician. London: Strahan and Cadell. (new ed.) Edinburgh: Creech.

View

Cullen W (1772)
Clinical lectures. Edinburgh, Feb-April, 218-219.

View

Sims J (1774)
A discourse on the best methods of prosecuting medical enquiries. London: J Johnson, p78-9, 80, 86-88, 99-101.

View

Lettsom JC (1775)
On the improvement of medicine in London on the basis of public good. London: Phillips.

View

Millar J (1777)
Observations on the practice in the medical department of the Westminster General Dispensary. London, by order of the Governors.

View

Millar J (1779)
Observations on the management of the prevailing diseases particularly in the Army and Navy. London, for the author.

View

Dobson M (1779)
A medical commentary on fixed air. Chester: J. Monk.

View

Home F (1780)
Clinical experiments, histories and dissections. Edinburgh: Creech; London: Murray.

View

Clark J (1780)
Observations on fevers, especially of the continued type. London: T Cadell.

View

Black W (1782)
An historical sketch of medicine and surgery from their origin to the present time. London: J Johnson.

View

Lavoisier A-L de (1784)
Undated documents contained in: Mémoires de Lavoisier, Oeuvres, Tome III. Paris: Imprimerie Impériale, 1865. p 509.

View

Commission Royale. Bailly A (1784)
Rapport des commissaires chargés par le Roi, de l'examen du magnétisme animale [Report of the Comissioners required by the King to examine animal magnetism]. Imprimé par ordre du Roi. Paris: A Paris, de L'Imprimerie Royale.

View

Fowler T (1785)
Medical reports of the effects of tobacco in the cure of dropsies and dysuries.... London: J Johnson.

View

Fowler T (1786)
Medical reports of the effects of arsenic in the cure of agues, remitting fevers and periodic headachs. London: J Johnson, pp 105-107.

View

Percival T (1788)
Essays medical, philosophical and experimental Vol 1.4th ed. Warrington: Eyres, for London: Johnson.

View

Black W (1788)
A comparative view of the mortality of the human species at all ages. London: Dilly, pp 35-38.

View

Gordon A (1788)
The practice of physick. Unpublished manuscript.

View

Hunter J (1788)
A treatise on the venereal disease. London: G Nicol and J Johnson, pp 69-70.

View

Robertson R (1789)
Observations on jail, hospital, or ship fever. New ed. London: for the Author.

View

Black W (1789)
An arithmetical and medical analysis of the diseases and mortality of the human species. London: J Johnson.

View

Robertson R (1790)
Essay on fever. London: printed for the author.

View

Ferriar J (1792)
Medical histories and reflections. Vol 1. London: Cadell and Davies.

View

Trotter T (1792)
Observations on the scurvy. London: Longman, pp 137-138, 184.

View

Clark J (1792)
Observations on the diseases which prevail in long voyages to hot countries. London: J Murray.

View

Rowley W (1793)
The causes of a great number of deaths amongst adults and children. 2nd edn. London: Newbery.

View

Fordyce G (1793)
An attempt to improve the evidence of medicine. Transactions of a Society for the Improvement of Medical and Chirurgical Knowledge.  London: J Johnson.

View

Hunter J (1794)
A treatise on the blood, inflammation and gun-shot wounds. London: G Nichol, p 531.

View

Ferriar J (1795)
Medical histories and reflections. Vol. 2. London: Cadell and Davies.

View

Fordyce G (1798)
A third dissertation on fever, Parts I & II. London: J Johnson.

View

Fordyce G (1802)
A second dissertation on fever. London: J Johnson.

View

Fordyce G (1803)
A fifth dissertation on fever. London: J Johnson.

View

Currie W (1804)
Medical reports of the effects of water: cold and warm as a remedy in fever and febrile diseases. Vol. 2. London: M’Creery & Cadell.

View

Blane G (1813)
Observations on the comparative prevalence, mortality, & treatment of different diseases.... Medico-chirurgical Transactions, Vol 4, p 89-141, London.

View

Guthrie GJ (1815)
A treatise on gun-shot wounds. London: Burgess and Hill.

View

Hutchinson AC (1817)
Some further observations on the subject of the proper period for amputating in gun-shot wounds. London: Callow, p16.

View

Marcet A (1819)
An essay on the chemical history and medical treatment of calculous disorders. London: Longman, Hurst, Rees, Orme and Brown.

View

Prout WM (1821)
An inquiry into the nature and treatment of gravel, calculus and other diseases connected with a deranged operation of the urinary organs. London: Baldwin, Cradock and Joy.

View

Richerand A (1825)
Histoire des progrès récens de la chirurgie [History of recent progress in surgery]. Paris: Béchet le Jeune, p 27.

View

Magendie F (1829)
Formulaire pour la préparation et l'emploi de plusieurs médicaments. Paris, imprimerie de Plassan,1ère édition.

View

Yelloly J (1829)
Remarks on the tendency to calculous diseases with observations on the nature of urinary concretions. Philosophical Transactions of the Royal Society 119: 55-81.

View

Hawkins FB (1829)
The elements of medical statistics. London: Longman, Rees, Orme, Brown & Green.

View

Todd TJ (1831)
The book of analysis or a new method of experience whereby the induction of the Novum Organon [of Bacon] is made easy of application to medicine, physiology… London, Murray.

View

Ministry of Internal Affairs (1832)
[Conclusion of the Medical Council regarding homeopathic treatment] . Zhurnal Ministerstva Vnutrennih del;3:49-63.

View

Bostock J (1833)
History of medicine. In: Forbes et al. eds. The cyclopaedia of practical medicine. Vol 1. Sherwood et al.: London, pp i-lxxii (see p lxix).

View

Hunter J (1835)
The works of John Hunter FRS, edited by James F Palmer, Vol 1. London: Longman et al., p 360.

View

Bigelow J (1835)
A discourse on self-limited diseases, delivered before the Massachusetts Medical Society at their annual meeting, May 27, 1835. Boston: Nathan Hale p 8-10.

View

Louis PCA (1835)
Recherches sur les effets de la saignée dans quelques maladies inflammatoires et sur l'action de l'émétique et des vésicatoires dans la pneumonie [Research on the effects of bloodletting in some inflammatory illnesses and on the action of emetics and blistering in pneumonia]. Paris: Librairie de l'Académie royale de médecine.

View

Louis PCA (1837)
The applicability of statistics to the practice of medicine. London Medical Gazette 20 :488-491.

View

Alcock R (1840)
Observations on injuries of joints and their treatment. Medico - chirurgical Transactions 23: 243-322.

View

Gavarret LDJ (1840)
Principes généraux de statistique médicale: ou développement des régles qui doivent présider à son emploi [General principles of medical statistics: or the development of rules that must govern their use]. Paris: Bechet jeune & Labé.

View

Alcock R (1840-41a)
Lectures on amputations and on the nature, progress and termination of the injuries for which it is required (Lecture 1 of 20). Lancet 1:105-111 and passim up to 2:849—858.

View

Alcock R (1840-41b)
Lectures on amputations and on the nature, progress and termination of the injuries for which it is required (Lecture 2 of 20). Lancet 1:217-220 and passim up to 2:849—858.

View

Bartlett E (1844)
An essay on the philosophy of medical science. Philadelphia: Lea and Blanchard.

View

Forbes J (1846)
Homoeopathy, allopathy and “young physic”. British and Foreign Medical Review 225-265.

View

Balfour TG (1854)
Quoted in West C. Lectures on the Diseases of Infancy and Childhood. London, Longman, Brown, Green and Longmans, p 600.

View

Holmes OW (1861)
Currents and countercurrents in medical science with other addresses and essays. Boston: Ticknor and Fields, 1861.

View

Mill JS (1862)
A system of logic ratiocinative and inductive. 5th Edn,vol 1. London:Parker, Son and Bourn, pp418,431-3.

View

Béclard PA (1863)
Rapport général sur les prix décernés en 1862 [General report on the prizes awarded in 1862]. Mémoires de l’Académie Impériale de Médecine XXVI, Paris: Ballière, pp. xxii-xxxv.

View

Flint A (1863)
A contribution toward the natural history of articular rheumatism; consisting of a report of thirteen cases treated solely with palliative measures. American Journal of the Medical Sciences 46:17-36.

View

Barclay AW (1864)
Medical errors: fallacies connected with the application of the inductive method of reasoning to the science of medicine. London: Churchill, p 55 and 71-73.

View

Bennett JH (1865)
The restorative treatment of pneumonia. Edinburgh, AC Black.

View

Sutton HG (1865)
Cases of rheumatic fever treated for the most part by mint water. Guy’s Hospital Reports 2:392-428.

View

Bernard C (1865)
Introduction à l'étude de la médicine expérimentale [Introduction to the study of experimental medicine]. Paris: Flammarion.

View

Bain A (1870)
Logic. London: Longmans, Green, Reader & Dyer p 362.

View

Wanscher O (1877)
Om Diphteritis og Croup - særligt med hensyn til Tracheostomien ved samme. [On diphtheria and croup - especially regarding tracheostomy in this condition]. Disputats [Thesis]. Jacob Lund: Kjøbenhavn, p 67-68.

View

O’Dwyer J (1887)
Fifty cases of croup in private practice treated by intubation of the larynx, with a description of the method and of the dangers incident thereto. Medical Record 32:557-561.

View

Moll A (1891)
Hypnotism. London: Walter Scott, p 224.

View

Andrew J (1891)
Harveian Oration. London: Adlard and Son. p 16-19.

View

Behring EA, Boer NN, Kossel H (1893)
Zur Behandlung diphtheriekranker Menschen mit Diphtherieheilserum [On the treatment of diphtheria patients with curative diphtheria serum]. Deutsche Medicinische Wochenschrift 17:389-39.

View

Ephraim A (1893)
Uber die Bedeutung de statistischen Methode für die Medicin [On the relevance of the statistical method for medicine]. Volkmann’s Sammlung Klinische Vortraege N.F. Innere Medicin 24:706-716. Leipzig: Breitkopf and Härtel.

View

Haffkine WM (1896)
Correspondence: Explanation of his inoculation report forms. Indian Medical Gazette 31:189-190.

View

Heiberg P (1897)
Studier over den statistiske undersøgelsesmetode som hjælpemiddel ved terapeutiske undersøgelser [Studies on the statistical study design as an aid in therapeutic trials]. Bibliotek for Læger 89:1-40.

View

Hulshoff-Pol MDJ (1902)
Katjang idjo, un nouveau medicament contre le béri-béri [Katjang idjo (mung beans), a new treatment for beri-beri]. Janus 7:524-581.

View

Rosenbach O (1905)
Die Diagnose als ätiologischer Factor [The diagnosis as a factor in aetiology]. Zeitschrift fur klinische Medicin 56:232-240.

View

Rivers WHR (1908)
The influence of alcohol and other drugs on fatigue. London: Edward Arnold.

View

Freeman J (1910)
Vaccine therapy. Proceedings of the Royal Society of Medicine 3:97-101.

View

Barnes HL (1912)
Report of 150 cases of pulmonary tuberculosis treated with tuberculin. JAMA 59:332-33.

View

Council on Pharmacy and Chemistry (1917)
Biniodol. JAMA 68: 650-51.

View

Sollmann T (1917)
The crucial test of therapeutic evidence. JAMA 69:198-199.

View

Bleuler E (1919)
Das Autistisch-Undisziplinierte Denken in der Medizin und Seine Überwindung [Autistic-undisciplined thinking in medicine and how to overcome it]. Berlin: Springer.

View

Greenwood M (1924)
Is the statistical method of any value in medical research? Lancet 2: 153-158.

View

Locke EA (1924)
The serologic treatment of lobar pneumonia. Boston Medical and Surgical Journal 190:196-203.

View

Swellengrebel NH (1925)
A summary of the more important facts on adult anophelines and their larvae observed by us or brought to our notice duing our tour through eastern Europe and Italy (May-September 1924). pp183-190. In: Malaria Commission of the Health Organisation (1925). Report on its tour of investigation in certain European countries in 1924. Geneva: League of Nations. C.H. 273.

View

Malaria Commission of the Health Organisation (1925)
Report on its tour of investigation in certain European countries in 1924. Geneva: League of Nations. C.H. 273.

View

Lewis S (1925)
Arrowsmith. New York: Collier.

View

Bullowa JGM (1928)
The control. Contribution to a symposium on the use of antipneumococcic refined serum in lobar pneumonia, 15 December 1927. Bulletin of the New York Academy of Sciences 4:339-343.

View

Medical Research Council Therapeutic Trials Committee (1934)
The serum treatment of lobar pneumonia. BMJ 1:241-245.

View

Greenwood M (1934)
Epidemics and crowd-diseases. Oxford: Oxford University Press.

View

Bentley PJ (1936)
Artificial pneumothorax: experience of the London County Council. Medical Research Council. London: Her Majesty's Stationary Office.

View

Sutliff WD (1936)
Adequate tests of curative therapy in man. Annals of Internal Medicine 1936-1937;10:89-97.

View

Bullowa JGM (1937)
Serum therapy. In: Bullowa JGM. The management of the pneumonias. New York: Oxford University Press, pp 283-298.

View

Editorial (1937)
Mathematics and medicine. Lancet 1:31.

View

Hill AB (1937)
Artificial pneumothorax on statistical trial. Lancet 229: 535-536.

View

Hill AB (1937)
Principles of medical statistics. I. The aim of the statistical method; and General summary and conclusions. Lancet 1:41-43 and 883-885.

View

Parrot A, Catanei A, Ambialet R, Clastrier J (1937)
Comparative experiments in mass prophylaxis of malaria by means of quinine and synthetic drugs (quinacrine and praequine). Bulletin of the Health Organization of the League of Nations 6:685-765.

View

Hill AB (1937)
Principles of medical statistics. London: Lancet.

View

Bahnsen P, Jacobsen E, Thesleff H (1938)
Studien über die Wirkung von beta-phenyl-isopropylaminsulfdat (Mecodrin) auf normale Menschen. [Studies on the effect of beta-phenyl-isopropylaminsulfdat (Mecodrin) on normal volunteers]. Klinische Wochenschrift 17:1074-1078.

View

Mainland D (1938)
The treatment of clinical and laboratory data: an introduction to statistical ideas and methods for medical and dental workers. Edinburgh: Oliver and Boyd.

View

Lanman TH, Heyl HL (1939)
Empyema in Children. New England Journal of Medicine 221:1003-1009.

View

Dahlberg G (1940)
Statistical methods for medical and biological students. London: George Allen & Unwin.

View

Gaddum JH (1940)
Pharmacology. London: Oxford University Press 378-383.

View

Hinshaw HC, Feldman WH (1944)
Evaluation of therapeutic agents in clinical tuberculosis. American Review in Tuberculosis 50:202-213.

View

Bell JA (1948)
The epidemiological principles and procedures involved in a study of the prophylactic value of an alum-precipated mixture of diphtheria toxoid and pertussis vaccine. Thesis submitted to the School of Hygiene and Public Health of the Johns Hopkins University in conformity with the requirements for the Degree of Doctor of Public Health.

View

Marshall EK (1949)
Clinical therapeutic trial of a new drug. Bulletin of the Johns Hopkins Hospital 85:221-230.

View

Reid DD (1950)
Statistics in clinical research. Annals of the New York Academy of Sciences 52:931-934.

View

Editorial (1950)
Are statistics necessary? JAMA 143:1260-1261.

View

Hill AB (1951)
The clinical trial. British Medical Bulletin 7:278-282.

View

Daniels M (1951)
Clinical evaluation of chemotherapy in tuberculosis. British Medical Bulletin 7:320-326.

View

Powers E, Witmer HL (1951)
An experiment in the prevention of delinquency: the Cambridge-Somerville Youth Study. New York: Columbia University Press.

View

Hill AB (1952)
The clinical trial. New England Journal of Medicine 247:113-119.

View

Gaddum JH (1954)
Clinical pharmacology. Proceedings of the Royal Society of Medicine 47:195-204.

View

Hogben L (1954)
The assessment of remedies. Medical Press 232:331-338.

View

Herdan G (1955)
Statistics of Therapeutic Trials. Amsterdam: Elsevier.

View

Lasagna L (1955)
The controlled clinical trial: theory and practice. Journal of Chronic Diseases 1:353-367.

View

Bjerkelund CJ (1957)
The effect of long-term treatment with dicoumarol in myocardial infarction. A controlled clinical study. Acta Med Scand Suppl 330:1-212.

View

Symposium on Clinical Trials RSM (1958)
Report of a meeting held at the Royal Society of Medicine, London on 25th April 1958.

View

Kerr DNS, Davidson S (1958)
Gastrointestinal intolerance to oral iron preparations. Lancet 2:489-492.

View

Cox DR (1958)
Planning of experiments. London: Wiley.

View

Waife SO, Shapiro AP (1959)
The clinical evaluation of new drugs. New York: Hoeber-Harper.

View

Bull JP (1959)
The historical development of clinical therapeutic trials. Journal of Chronic Diseases 10:218-248.

View

Witts LJ (1959)
Medical surveys and clinical trials: some methods and applications of group research in medicine. Oxford: Oxford University Press.

View

Oldham PD (1959)
Clinical and field trials. Acta Medica Hungarica 14:313-326.

View

Doll R (1959)
Practical problems of drug trials in clinical practice. Lawrence DR, ed. Quantitative methods in human pharmacology and therapeutics. Oxford: Pergamon Press, pp. 213-221.

View

Schwartz D, Flamant R, Lellouch J, Rouquette C (1960)
Les essais thérapeutiques cliniques [Controlled clinical trials]. Paris: Masson.

View

Hill AB (1960)
Controlled clinical trials. Oxford: Blackwell Scientific Publications.

View

Zubrod CG, Schneiderman M, Frei E, Brindley C, Gold GL, Shnider B, Oviedo R, Gorman J, Jones R, Jonsson U, Colsky J, Chalmers T, Ferguson B, Dederick M, Holland J, Selawry O, Regelson W, Lasagna L, Owens AH (1960)
Appraisal of methods for the study of chemotherapy in man: Comparative therapeutic trial of nitrogen mustard and thiophosphoramide. Journal of Chronic Diseases 11:7-33.

View

Cochran WG (1961)
Designing clinical trials. In: Forster FM, ed. Evaluation of drug therapy. University of Wisconsin Press, pp 71-77.

View

Hill AB (1962)
Alfred Watson Memorial Lecture: The Statistician in Medicine. Journal of the Institute of Actuaries 88:178-191. doi:10.1017/S0020268100014980

View

Schneiderman MA (1966)
Therapeutic trials in cancer. Working paper prepared for WHO Expert Committee on Cancer Treatment, Geneva, Switzerland, 9-15 March 1965. WHO/CANC/66.66.

View

Schwartz D, Lellouch J (1967)
Explanatory and pragmatic attitudes in therapeutic trials. Journal of Chronic Diseases 20:637-48.

View

Chalmers TC (1968)
When should randomisation begin? Lancet 1:858.

View

Ley HL (1969)
Antibiotic drugs: procedural and interpretive regulations. Federal Register Vol. 34, No. 180, pp14596-597.

View

Schwartz D, Flamant R, Lellouch J (1970)
L’essai thérapeutique chez l‘homme. Paris: Flammarion.

View

Cornfield J (1971)
The University Group Diabetes Program: a further statistical analysis of the mortality findings. JAMA 217:1676-87.

View

Chalmers TC (1975)
Randomization of the first patient. Medical Clinics of North America 59:1035-1038.

View

Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1976)
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. British Journal of Cancer 34:585-6.

View

Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977)
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. British Journal of Cancer 35:1-39. PMID 831755.

View

Pocock SJ (1977)
Randomised clinical trials. BMJ 1:1661.

View

Bunker JP, Barnes BA, Mosteller F (1977)
Costs, risks and benefits of surgery. Oxford: Oxford University Press.

View

Farquhar JW (1978)
The community-based model of life style intervention trials. American Journal of Epidemiology 108:103-111.

View

Sackett DL (1979)
Bias in analytic research. Journal of Chronic Diseases 32:51-63.

View

Chalmers TC, Smith JH, Blackburn B, Silverman B, Schroeder B, Reitman D, Ambroz A (1981)
A method for assessing the quality of a randomized control trial. Controlled Clinical Trials 2: 31-49.

View

Pocock SJ (1983)
Clinical trials: a practical approach. Chichester: John Wiley.

View

Bulpitt CJ (1984)
Randomised controlled clinical trials. The Hague: Martinus Nijhoff.

View

Peto J, Eden OB, Lilleyman J, Richards S (1986)
Improvement in treatments for children with acute lymphoblastic leukaemia: The Medical Research Council UKALL Trials, 1972-84. Lancet 1:408-411.

View

Machin D, Campbell MJ (1987)
Statistical Tables for the Design of Clinical Trials. Oxford: Blackwell scientific publications.

View

Jenicek M (1987)
Méta-analyse en médecine. Évaluation et synthèse de l’information clinique et épidémiologique. [Meta-analysis in medicine: evaluation and synthesis of clinical and epidemiological information] St.Hyacinthe and Paris: EDISEM and Maloine Éditeurs.

View

Chalmers TC (1988)
Data analysis for clinical medicine: the quantitative approach to patient care in gastroenterology. Rome: International University Press.

View

O’Rourke K, Detsky AS (1989)
Meta-analysis in medical research: strong encouragement for higher quality in individual research efforts. Journal of Clinical Epidemiology 42:1021-24.

View

Pocock SJ, Hughes MD (1989)
Practical problems in interim analyses, with particular regard to estimation. Control Clinical Trials10 (4 Suppl):209S-221S.

View

Jenicek M (1989)
Meta-analysis in medicine: where we are and where we want to go. Journal of Clinical Epidemiology 42:35-44.

View

Donner A, Brown KS, Brasher P (1990)
A methodological review of non-therapeutic intervention trials employing cluster randomization, 1979-1989. International Journal of Epidemiology 19:795-800.

View

Chalmers I (1991)
The perinatal research agenda: whose priorities? Birth 18(3), 137-41.

View

Simpson JM, Klar N, Donner A (1995)
Accounting for cluster randomization: a review of primary prevention trials, 1990 through 1993. American Journal of Public Health 85:1378-1383.

View

Chalmers I (1995)
What do I want from health research and researchers when I am a patient? BMJ 310(6990), 1315-8.

View

Murray DM (1998)
Design and Analysis of Group Randomized Trials. New York: Oxford University Press Inc.

View

Fitzpatrick R, Davey C, Buxton MJ, Jones (1998)
Evaluating patient-based outcome measures for use in clinical trials. Health Technology Assessment 2(14), i-iv, 1-74.

View

Sutton AJ, Abrams KR, Jones DR, Sheldon T, Song F (2000)
Methods for Meta-Analysis in Medical Research. Chichester: Wiley.

View

Stangl D, Berry DA (2000)
Meta-Analysis in Medicine and Health Policy. New York: Marcel Dekker, Inc.

View

Sandercock P, Roberts I (2002)
Systematic reviews of animal experiments. Lancet 360:586. DOI:https://doi.org/10.1016/S0140-6736(02)09812-4.

View

Jones B, Kenward MG (2003)
Design and Analysis of Cross-Over-Trials (2nd Ed). London and USA: Chapman and Hall.

View

Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock S, Macleod M,  Mignini LE, Jayaram P, Khan KS (2007)
Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 334:197-200.

View

Djulbegovic B, Kumar A, Soares HP, Hozo I, Bepler G, Clarke M, Bennett CL (2008)
Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the national cancer institute-sponsored cooperative oncology groups, 1955 to 2006. Archives of Internal Medicine. 168:632-42.

View

Smith V, Clarke M, Devane D, Begley C, Shorter G, Maguire L (2013)
SWAT 1: what effects do site visits by the principal investigator have on recruitment in a multicentre randomized trial? Journal of Evidence-Based Medicine 6(3), 136-137 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.12049

View

Chalmers I, Atkinson P, Fenton M, Firkins L, Crowe S, Cowan K (2013)
Tackling treatment uncertainties together: the evolution of the James Lind Initiative, 2003-2013. Journal of the Royal Society of Medicine 106(12), 482-91.

View

Wartolowska K, Judge A, Hopewell S, Collins GS, Dean BJF, Rombach I, Brindley D, Savulescu J, Beard DJ, Carr AJ (2014)
Use of placebo controls in the evaluation of surgery: systematic review. BMJ 348:g3253. doi: 10.1136/bmj.g3253.

View

Wartolowska KA, Collins GS, Hopewell S, Judge A, Dean BJF, Rombach I, Beard DJ, Carr AJ (2016)
Feasibility of surgical randomised controlled trials with a placebo arm: a systematic review. BMJ Open 6: p.e010194.

View

Chalmers I (2017)
The evolution of fair tests of treatments over two millennia: a 23 minute audio commentary. Edited by Hamish Chalmers, using unbroadcast recordings made by Freakonomics Radio, with permission.

View

Horby P, Lim WS, Emberson J, Mafham M, Bell J, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffrey K, Montgomery A, Rowan K, Juszcak E, Baillie JK, Haynes R, Landray MJ, on behalf of the RECOVERY Collaborative Group (2020)
Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report. medRχiv. Doi: https://doi.org/10.1101/2020.06.22.20137273

View

Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse A, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell L, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ (2020)
Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. doi: https://doi.org/10.1101/2020.07.15.20151852

View

RECOVERY Trial Team (2020)
Randomized Evaluation of COVID019 Therapy (RECOVERY). RECOVERY Central Coordinating Office, Oxford. www.recoverytrial.net

View

Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM, García CH, Kieny MP, Malekzadeh R, Murthy S, Preziosi MP, Reddy S, Periago MR, Sathiyamoorthy V, Røttingen JA, Swaminathan S, WHO Solidarity trial consortium (2020)
Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results. MedRxiv. doi: https://doi.org/10.1101/2020.10.15.20209817

View

Naidoo N, Nguyen VT, Ravaud P, Young B, Amiel P, Schanté D, Clarke M, Boutron I (2020)
P, Young B, Amiel P, Schanté D, Clarke M, Boutron I (2020). The research burden of randomized controlled trial participation: a systematic thematic synthesis of qualitative evidence. BMC Medicine 18, 6. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1476-5

View

Coleman E, Arundel C, Clark L, Doherty L, Gillies K, Hewitt C, Innes K, Parker A, Torgerson D, Treweek S (2021)
Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials. BMJ 375, e067742. https://www.bmj.com/content/375/bmj-2021-067742.long

View

Chesire F, Mugisha M, Ssenyonga R, Rose CJ, Nsangi A, Kaseje M, Sewankambo NK, Oxman M, Rosenbaum SE, Moberg J, Dahlgren A, Lewin S, Oxman AD (2023)
Effects of the Informed Health Choices secondary school intervention: A prospective meta-analysis. Journal of Evidence Based Medicine 16, 321-331. https://onlinelibrary.wiley.com/doi/10.1111/jebm.12552

View

Turner KM, Huntley A, Yardley T, Dawson S, Dawson S (2024)
Defining usual care comparators when designing pragmatic trials of complex health interventions: a methodology review. Trials 25, 117. https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07956-7

View

Show


Donaldson IML (2016).
Reflections on translating passages on ‘empirical’ and ‘dogmatic’ medicine in Celsus’s De medicina. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Bishop D, Gill E (2019).
Robert Boyle on the importance of reporting and replicating experiments. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Marson Smith P, Colquhoun D, Chalmers I (2019).
John Henry Gaddum’s 1940 guidance on controlled clinical trials JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Tröhler U (2020)
Probabilistic thinking and the evaluation of therapies, 1700-1900. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Williams AN, O’Dell FJ, Aronson JK (2020).
Was William Harvey’s commitment to experimentation reflected in his clinical practice? JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Clarke M (2021).
The true meaning of DICE: Don’t Ignore Chance Effects JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Held L, Matthews RAJ (2022).
Paradigm lost: Carl Liebermeister and the development of modern medical statistics. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Ritskes-Hoitinga M, Pound P (2022).
The role of systematic reviews in identifying the limitations of preclinical animal research, 2000 – 2022. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Chalmers I, Matthews R, Glasziou P, Boutron I, Armitage P† (2023).
Analysis of clinical trial by Treatment Allocated or by Treatment Received? Applying ‘the intention-to-treat principle’. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Nylenna, M (2023).
Paul Owren, Christopher Bjerkelund and the dawn of controlled trials in Norway. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Glasziou P, Matthews R, Boutron I, Chalmers I, Armitage P† (2023)
The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective. JLL Bulletin: Commentaries on the history of treatment evaluation.

View

Big Data, Big Bias? Evidence on the effects of selection bias in large observational studies

View